Druginduced myopathy ranges from mild myalgias with or without mild weakness to chronic myopathy with severe weakness and to massive rhabdomyolysis with acute renal failure. Clotting disorders, anemias, hematologic malignancies, coagulopathies, thrombotic disorders, hemoglobinopathies, lymphoproliferative disorders, plasma cell disorders,and immunologic and. From there, you can view and download your ashp ebooks to the reader of your choice. Because druginduced blood disorders are potentially dangerous, rechallenging a patient with a suspected agent in an attempt to confirm a diagnosis is not generally recommended. Drug induced neutropenia is a potentially serious and lifethreatening adverse event that may occur secondary to therapy with a variety of agents. Educating patients about these risks and remaining vigilant in clinical investigations of unusual adverse effects are key elements to increasing the safety of drug. Drug induced hematological disorders barbra doziers blog. Blood disorders, many of which carry an attendant high morbidity or mortality, constitute a significant part of druginduced problems. Never prescribed, commonly administered pharmaceutical medicine. Anemia, drug induced immune hemolytic medication list about anemia, drug induced.
This drug induced hematological disorders span the whole range of body hematology affecting red blood cells, platelets, coagulation system, and the white blood cells. Ashp ebooks sign in with your ashp username and password to access purchased ebooks in my library. Druginduced blood disorders journal of clinical pathology. This medication may not be approved by the fda for the treatment of this condition. Full text full text is available as a scanned copy of the original print version. Ppt druginduced kidney disease powerpoint presentation. A full team of experts and specialists is dedicated to each child. Drug induced kidney disease 1 drug induced kidney disease 2 introduction. Drug induced myopathy ranges from mild myalgias with or without mild weakness to chronic myopathy with severe weakness and to massive rhabdomyolysis with acute renal failure.
Druginduced hematologic disorders are more common in the elderly than in the young. Aplastic anemia is usually treated with blood transfusions. If you continue browsing the site, you agree to the use of cookies on this website. Druginduced hematologic disorders pocket icu management. Icd10 cm clinical codes external look up icd10 codes for blood disorders on. Drugs can produce toxicity through three major mechanisms. Although the precise incidence is unknown, druginduced myopathy is among the most common causes of muscle disease. Blood disorders detection and treatment health articles 101.
Druginduced endocrine and metabolic disorders springerlink. Drug induced anaemia is a condition in which the body does not have enough healthy red blood cells resulting from the administration of a drug. They enhance sodium delivery to the distal nephron leading. Drugs can induce almost the entire spectrum of hematologic disorders, affecting white cells, red cells, platelets, and the.
Immunosuppressants can treat autoimmune related blood disorders while hormonal injection and. The most common druginduced hematologic disorders include aplastic anemia, agranulocytosis, megaloblastic anemia, hemolytic anemia, and thrombocytopenia. Blood disorders treatment university of vermont medical. Review article druginduced hematologic syndromes core. Druginduced neurologic conditions may result from singleagent drug regimens, but they are more likely to occur when multiple agents that confer risk are administered concomitantly. Usually, druginduced hypertension is of a transient nature, and a careful evaluation of the individuals drug regimen may help identify the drug causing high blood pressure the common signs and symptoms of druginduced hypertension include headache, lightheadedness, nausea, vomiting, muscle tremors, and excessive sweating. It is a cofactor in over 300 enzymatic reactions in the body. Belcher slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. The four major blood dyscrasias attributable to drugs are.
However, given the high rates of cardiovascular disease and prevalence of recognised cardiovascular risk factors in the population, it is sometimes impossible to conclusively. This thickened more viscous blood may have difficulty passing through small blood vessels, decreasing blood flow to certain areas of the body, which is a serious condition called hyperviscosity. Apr 30, 2020 drug induced neurologic conditions may result from singleagent drug regimens, but they are more likely to occur when multiple agents that confer risk are administered concomitantly. Therapy drug induced hematologic disorders quizlet.
Anemia, hemolytic anemia, megaloblastic anemia, methemoglobinemia, polycythemia, red blood cells, side effects, sideroblastic anemia, druginduced immune hemolytic anemia, antineoplastics. This paper aims to emphasize the broad range of druginduced hematological syndromes and to highlight some of the newer drugs and syndromes. These tend to be relatively common, are always serious, and frequently can be lifethreatening. Drugs can affect all types of blood cells and induce different disorders. Start studying therapy drug induced hematologic disorders. Low levels can lead to heart irregularities, elevated blood pressure. We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. Classical causes of druginduced thrombocytopenia are the quinine and quininelike drug s 36. The mechanisms of druginduced hematologic disorders can be the result of either direct drug or metabolite toxicity or an immune reaction. Miller, with contributions from experts distinguished in their respective specialties, drug induced diseases is the musthave resource for pharmacists, physicians, nurses, and pharmacy students alike. Drugs can induce almost the entire spectrum of hematologic disorders, affecting white cells, red cells, platelets, and the coagulation system. Protein s deficiency 3 drugs pure red cell aplasia 0 drugs learn more about blood disorders.
Recognition and management of druginduced blood disorders. Management of bleeding disorders poses a challenge to dentists. Blood disorders symptoms, causes, diagnosis, blood. Chronic druginduced skin disorders druginduced lupus dil. Several medications have been linked to red blood cell rbc disorders. Druginduced hematological disorders can span almost the entire spectrum of hematology, affecting red cells, white cells, platelets, and the coagulation system. Nov 19, 20 this drug induced hematological disorders span the whole range of body hematology affecting red blood cells, platelets, coagulation system, and the white blood cells. The frequency of these side effects varies, depending on the. Druginduced anemias are po tentially dangerous and have. Druginduced hypoglycemia is a condition when blood glucose level drops below 70 mgdl in response to certain types of medication alcohol, excessive physical activity, and overdosing on diabetic medications are risk factors for druginduced hypoglycemia. Druginduced megaloblastic, aplastic, and hemolytic anemias. It is necessary for the transmission of nerve impulses, muscular activity, temperature regulation, detoxification reactions, and formation of healthy bones. International journal of hematology and blood disorders.
Jude doctors and researchers have developed and improved treatments for children with noncancerous hematological blood disorders. Druginduced blood disorders free download as word doc. Reported adverse health effects in children from ingestion of alcoholbased hand sanitizers united states. A casehistory study of druginduced blood disorders pancytopenia, hemolytic anemia, thrombocytopenia, and granulocytopenia was carried out at the group. As the variety and range of pharmaceutical agents available to the medical profession continues to expand, one unavoidable effect will be an increase in drug induced disease, including cardiovascular disorders. As the variety and range of pharmaceutical agents available to the medical profession continues to expand, one unavoidable effect will be an increase in druginduced disease, including cardiovascular disorders. Blood disorders united states pdf ppt case reports. List of anemia, drug induced medications 4 compared. Journal of blood disorders and treatment open access journals. Drug induced anaemia and other blood disorders are potentially. The most common druginduced hematologic disorders include aplastic anemia, agranulocytosis, megaloblastic anemia, hemolytic anemia, and. Although the precise incidence is unknown, drug induced myopathy is among the most common causes of muscle disease.
Drug induced hematology lecturer nin prapongsena huachiew chalermprakiet university 2. T he mechanisms of druginduced hematologic disorders can be the result of either direct drug or metabolite toxicity or an immune reaction. These conditions can be inherited, acquired, or congenital are associated with an increased risk of hemorrhage, poor wound healing. Thank you for your interest in spreading the word about the bmj. Drug induced hematologic disorders is a topic covered in the pocket icu management to view the entire topic, please sign in or purchase a subscription anesthesia central is an allinone web and mobile solution for treating patients before, during, and after surgery. Drug induced blood disorders have also been the reason for withdrawal for a number of drugs, notably remoxipride in 1994. Get a printable copy pdf file of the complete article 223k, or click on a page image below to browse page by page. Drugs induced hematology platelet disorders blood disorders anemia neutropenia thrombocytopenia thrombosis 4. The kidney is particularly vulnerable to drugs and other agents that cause renal damage.
Learn vocabulary, terms, and more with flashcards, games, and other study tools. Hematologic disorders have long been a potential risk of modern pharmacotherapy. Immunological mechanisms in druginduced blood dyscrasias. Some blood disorders cause a persons blood to become thickened by increased quantities of immunerelated proteins, red blood cells, or platelets. Warning signs of nsaidinduced gastric irritation severe abdominal crampspain. Most genetic blood disorders are usually detected early in childhood such as hemophilia, sickle cell anemia and thalassemia, just to name a few. Stroncek a large number of drugs have been found to cause neutropenia. Drug induced pseudorenal failure bun due to protein catabolism steroids, tetracyclines scr due to competitive inhibition of creatinine secretion trimethoprim, cimetidine, triamterene with trimethoprim 1535% rise scr fully expressed after 3 days more sig in pts with preexisting renal dysfunction can occur with normal doses completely. Switch to rx wlower risk in same category immunologic.
Pdf druginduced hematologic syndromes researchgate. The first page of the pdf of this article appears above. Anemia, hemolytic anemia, megaloblastic anemia, methemoglobinemia, polycythemia, red blood cells, side effects, sideroblastic anemia, drug induced immune hemolytic anemia, antineoplastics. This rare adverse effect occurs in approximately 15,000 to 30,000 individuals per year in the united states. Anemia can be treated with iron supplementation while the causative factor is discovered.
Large doses of benzylpenicillin penicillin g may promote urinary potassium excretion by acting as nonreabsorbable anions in the distal renal tubule. Anemia, druginduced immune hemolytic medication list about anemia, drug induced. Druginduced hematologic disorders is a topic covered in the pocket icu management to view the entire topic, please sign in or purchase a subscription anesthesia central is an allinone web and mobile solution for treating patients before, during, and after surgery. Cytotoxic chemotherapy can cause a predictable and doserelated decrease in neutrophil count. Previous reports have demonstrated that pb intoxication, accompanied by high pb levels, can induce pancytopenia 6. The kidney maintains the vital functions of clearing excess body fluid and removing metabolic and exogenous toxins from the blood. Other causes include other diseases, side effects of medicines, and a lack of certain nutrients in your diet. Agranulocytosis or leukopenia loss of the white blood cells aplastic anemia loss of all the formed elements of the blood thrombocytopenia loss of the platelets hemolytic anemia loss of the red. Blood disorders affect one or more parts of the blood and prevent your blood from doing its job. Some agents causes predictable hematologic disease e. Druginduced kidney disease 1 druginduced kidney disease 2 introduction. Warning signs of nsaid induced gastric irritation severe abdominal crampspain. Drugs induced platelet disorders thrombocytopenia thrombosis 5. Switch to rx wlower risk in same category immunologic rx.
B ecause druginduced blood disorders are potentially dangerous, rechallenging a patient with a suspected agent in an attempt to confi rm a diagnosis is not generally recommended. Its exact incidence is diffi cult to document but about 40,000 to 45,000 people may experience a druginduced liver injury each year. Many drugs or their metabolites are directly toxic to bone marrow and thus inhibit the production of neutrophils. Hematology is a field of medicine that studies symptoms, early detection and treatment of genetic and acquired blood disorders ranging from mild to moderate and to severe life threatening conditions. Agranulocytosis or leukopenia loss of the white blood cells aplastic anemia loss of all the formed elements of the blood thrombocytopenia loss of the platelets hemolytic anemia loss of the red blood. Of course, some blood disorders or diseases are much more intensive to treat than others. Druginduced hematological disorders can span almost the entire spectrum of hematology, affecting red cells, white cells, platelets, and the.
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